Stem Cells Therapy For Diabetic Foot Ulcers

What is Diabetic Foot Ulcer?

Diabetic foot ulcers (DFU) is one of the most common seen complications among people with diabetes. A Diabetic foot ulcer is an open wound or sore on the skin that is slow to heal, which can have a profound impact on the morbidity, mortality and quality of life of patients.

The high blood sugar levels associated with diabetes can damage nerves and blood vessels over time, causing the blood supply to the feet to become significantly restricted. As a result, the feet receive a lower number of infection-fighting cells, which can lead to longer healing time.

Even a small cut or burn could lead to ulcers and infections. If a wound or sore becomes infected as a result of slow recovery time, there is a high risk that the tissue may gradually die. If this happens, the patient may need surgery to remove the damaged tissue and in severe cases, the toe or foot may need to be amputated.

Facts about Diabetic Foot Ulcers 

  • 415 million people in the world have diabetes
  • 10% of people with diabetes have a diabetic foot ulcer
  • 46% of people with diabetes are undiagnosed. The figure is expected to rise to 642 million people living with diabetes worldwide by 2040.
  • The number of people diagnosed with diabetes has doubled in 20 years.

Stages of Diabetic Foot Ulcers

Diabetic foot ulcers (DFU) are chronic wounds that are notoriously difficult to heal, thus leading to an exaggerated amputation rate in the diabetic population.

Stem Cell Therapy For Diabetic Foot Ulcers

How Stem Cell Therapy Can Help In Treating Diabetic Foot Ulcers

Stem cells, through their inherent ability to secrete pro-healing cytokines/growth factors and cellular differentiation capabilities, are a promising regenerative approach to assist in wound healing for DFU patients.

  • Mesenchymal stem cells have the potential to renew, replace, or repair the necrotic tissue by directly differentiating into effective cells to blend with damaged ones. 
  • The stem cells with the potential factors are able to suggestively activate and mobilize endogenous stem cells to reside in areas of tissue injury.
  • Mesenchymal stem cells accelerate wound healing via immune regulation and growth factor production, which in turn strengthen neovascularization and reepithelialization, restore angiogenesis, and promote resulting in the promotion of wound closure.

Stem cell therapy has been used as adjuvant therapy in the treatment of diabetic foot ulcers. This therapy can offer the potential for accelerating would healing, reducing infection and preventing re-ulceration – providing a potentially life-charging and sugery-free option for diabetic patients. 

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